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CXCL8 is a key mediator in the neutrophil infiltration into airway tissue by acting as a neutrophil chemoattractant

In contrast, later cohorts (19651985) benefited from stricter tobacco control policies, improved health education, and better access to medical resources, leading to a decline in smoking prevalence and a reduced disease burden

If we took a pragmatic harm-reduction approach, as other countries have done, we could use our very successful model of regulation of tobacco products as a template to achieve both outcomes

The following sections summarise the clinically relevant pharmacokinetic and pharmacodynamic interactions